Optimization of chlorpheniramine maleate (CPM) delivery by response surface methodology – four component modeling using various response times and concentrations of chitosan-alanine, glutaraldehyde and CPM
K. Kumari, K. Prasad, P. P. Kundu
Vol. 3., No.4., Pages 207-218, 2009
DOI: 10.3144/expresspolymlett.2009.27
DOI: 10.3144/expresspolymlett.2009.27
Corresponding author: K. Kumari 
GRAPHICAL ABSTRACT
ABSTRACT
The aim of the current study was to investigate the effects of formulation variables on the release of drug and to optimize the formulation of chitosan-alanine beads loaded with chlorpheniramine maleate (CPM) for controlled release using response surface methodology (RSM). Drug loaded beads of chitosan-alanine were prepared and crosslinked by using glutaraldehyde as crosslinker. The release behavior of drug was affected by preparation variables. A central composite design was used to evaluate and optimize the effect of preparation variables; chitosan concentration (X1), percentage of crosslinker (X2), concentration of drug (X3) and release time (X4) on the cumulative amount of drug release, Y in solutions of pH = 2.0 and pH = 7.4, respectively. The influence of each parameter was studied by factorial design analysis. Analysis of variance (ANOVA) was also used to evaluate the validity of the model. The statistical parameters reveal strong evidence that the constructed models for drug release in pH = 2 and pH = 7.4 are reliable.
